To take advantages of 3D printing technology in personalized wine packaging production, taking the paper-based 3D printing process as an example, three keynote issues including model designing, manufacturing process and quality evaluation, were analyzed and characterized to explore feasible solutions and specific rules from given cases study. Based on one Chinese wine brand, four original customized wine packaging models with different remarkable features were designed and compared by quantitative tests between the Cutting-Bonding Framework and printing time for each specimen. Considering specific supply chain of printed customized wine packaging models, the principles for marketing quality evaluation were mainly focused on surface color consistence and fragility, and corresponding evaluation frameworks were developed for printed wine packaging models. According to test results of designed cases for paper-based 3D printing, three practical solutions including models design rules, process optimization strategy and printing quality evaluation workflow were offered respectively and illustrated to contribute promising industrialization of the paper-based 3D printing technology in customized wine packaging applications.