Digital printing has begun to play an ever-increasing role in the commercial printing industry. The usual approach to tackle all imaging artifacts is to optimize each subsystem and hope the final assembled system will satisfy the product requirement. While the subsystem optimization is necessary, it might result in overstringent requirements for each subsystem, but still not address the problems from the interaction among subsystems. An efficient optimization process to compensating the residual image artifacts on an assembled printing press will address this deficiency to further reduce system manufacturing constraints and extend the life expectancy of imaging components. The Intelligent Calibration System is an adaptive digital press optimization process to address one-dimensional macro nonuniformity and color-to-color misregistration using its digital writing module and a fast image-capturing device.