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Volume: 25 | Article ID: art00113_1
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High-Fidelity Printing Strategies for Printing 3D Vascular Hydrogel Structures
K. Pataky
M. Ackermann
T. Braschler
M. Lutolf
P. Renaud
J. Brugger
  DOI :  10.2352/ISSN.2169-4451.2009.25.1.art00113_1  Published Online :  January 2009
Abstract

Vascularization arguably poses the most significant hurdle for the success of most biomaterials-based tissue engineering therapies. In this work, we report two printing strategies that permit the 3D Inkjet printing of fluorescent alginate hydrogels into overhanging structures and closed lumens that could serve as vessel mimetics. The first is 4-Matrix printing, where the order of droplet printing in each printing layer is optimized so that new droplets do not coalesce with un-gelled droplets on the surface. The second is the use of incremental droplet spacing to print overhanging and closed structures in order to reduce the degree of down-wall flow.Printed 3D structures were examined by 3D confocal microscopy in order to determine the effectiveness of these printing strategies. The results are promising and might be applied to other rapidly gelling hydrogel systems.

Journal Title : NIP & Digital Fabrication Conference
Publisher Name : Society of Imaging Science and Technology
Publisher Location : 7003 Kilworth Lane, Springfield, VA 22151, USA
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 DOI 10.2352/ISSN.2169-4451.2009.25.1.art00113_1
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K. Pataky, M. Ackermann, T. Braschler, M. Lutolf, P. Renaud, J. Brugger, "High-Fidelity Printing Strategies for Printing 3D Vascular Hydrogel Structures"  in Proc. IS&T Int'l Conf. on Digital Printing Technologies and Digital Fabrication (NIP25),  2009,  pp 411 - 414,  https://doi.org/10.2352/ISSN.2169-4451.2009.25.1.art00113_1

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Copyright © Society for Imaging Science and Technology 2009
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NIP & Digital Fabrication Conference
nip digi fabric conf
2169-4451
Society of Imaging Science and Technology
7003 Kilworth Lane, Springfield, VA 22151, USA
2169-4451(20090101)2009:1L.411;1-
nip_v2009n1/splitsection113.xml
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Articles
High-Fidelity Printing Strategies for Printing 3D Vascular Hydrogel Structures
PatakyK.
AckermannM.
BraschlerT.
LutolfM.
RenaudP.
BruggerJ.
01012009
2009
1
411
414
2009
Vascularization arguably poses the most significant hurdle for the success of most biomaterials-based tissue engineering therapies. In this work, we report two printing strategies that permit the 3D Inkjet printing of fluorescent alginate hydrogels into overhanging structures and closed lumens that could serve as vessel mimetics. The first is 4-Matrix printing, where the order of droplet printing in each printing layer is optimized so that new droplets do not coalesce with un-gelled droplets on the surface. The second is the use of incremental droplet spacing to print overhanging and closed structures in order to reduce the degree of down-wall flow.Printed 3D structures were examined by 3D confocal microscopy in order to determine the effectiveness of these printing strategies. The results are promising and might be applied to other rapidly gelling hydrogel systems.