Chromatic flare artifacts, purple flare in particular, are objectionable color artifacts affecting image quality in digital photography systems ranging from DSLR to mobile imaging cameras. Although they originate from internal reflections and scattering in the camera module, they can be diminished with proper pixel design strategies. This work presents a method to quantify an image sensor susceptibility to chromatic flare artifacts. It is based on measurements of the spectral response of pixels for varied angles of incidence, and subsequent analysis of color properties of synthetic images that are processed through a conventional pipeline. Experimental work has been done with image sensors that differ by their color filter array and grid properties. Results show that use of metal grid and deep trench isolation—state-of-the-art pixel fabrication approaches that were developed to suppress crosstalk—are advantageous for mitigation of chromatic flare artifacts.