Vesselness in an image is a map that conveys the extent to which certain image structures resemble blood vessels. The standard approach to this problem uses greyscale images. An earlier algorithm [1] derives a vesselness map for a colour image from the Hessian of a pure quaternion whose components are the colour channels. As an alternative to that method, we here divide the vesselness task into two parts: Convert the colour image to a grey image using the Fast Color2Grey algorithm [2, 3], and then use the traditional Frangi Hessian method [4] on that grey image to produce the vesselness map. Compared with the quaternion-based algorithm, the method proposed here is more accurate in identifying retinal blood vessels and also operates 104 times as fast.
Mark S. Drew, Ali Alsam, Ali Madooei, Michael H. Brill, "Fast Colour Vesselness" in Proc. IS&T 19th Color and Imaging Conf., 2011, pp 146 - 151, https://doi.org/10.2352/CIC.2011.19.1.art00030