Within Tissue Engineering one of the greatest challenges is providing cells in an engineered tissue with nutrients and oxygen via blood or serum. The process, otherwise known as perfusion, brings these vital supplies to within 100-200 microns of all cells by means of the vascular network. If perfusion is insufficient cells begin to die (necrosis) which effectively self-regulates cell growth to within 150-200 micron of a diffusive oxygen source and limits the useful thickness of cellularised tissue that can be engineered in vitro. A spectrum of research approaches ranging from cell-based therapies that attempt to induce spontaneous budding of capillary structures to scaffold based therapies that provide a spatial prevascular structure to guide the formation of the vascular network are currently being investigated. This contribution discusses the research that has been undertaken to indirectly fabricate prevascular scaffolds. Inkjet printing is used to make sacrificial three-dimensional microstructures that are initially employed in the production of the biomimetic 3D microfluidic devices. The process is complimented by the use of low temperature thermal phase change materials e.g. Hexadecane and Octadecane, as inks that enable structurally sound three-dimensional microstructures to be constructed, and then sacrificed without damage to the biocompatible materials (gelatin with a variety of cross linking mechanisms) used for the prevascular scaffold.