The property of printing substrate plays an important role in the image reproduction of ink-jet printing. The paper's properties such as roughness, gloss, surface wettability and other factors have great influence on the dot reproduction attributes of presswork. The main purpose of this paper is to provide a new method to analyze the influence of paper's properties on the dot reproduction. Different paper factor has different effect weight on the image reproduction. The grey relational analysis is a multi-factor statistical analysis method, which is based on the sample data and the grey incidence of various factors and is used to describe the strength, size and the order of the relationship between the factors. The grey relational analysis is applied to analyze the influence law and the effect weight of paper factors on the dot reproduction during ink-jet printing, which could provide theoretical guidance for improving the printability of paper. In this experiment, five types of ink-jet printing paper were used to test their printing performance, and then the dot gain data were dealt with by the grey relational analysis method. The parameters of the inkjet printer were adjusted to match the paper type. And then, the CMYK step-wedges designed by Adobe Photoshop CS were printed by the printer with 600dpi print resolution. The step-wedge consisted of the color patches with 1%, 2%, 5%, 25%, 50% and 75% dot coverage respectively. The printed dots were taken photos by Microscope to analyze the ink setting condition. The dot gains of highlights, mid-tone and shadow area in each printed sample were measured by the spectrophotometer. At last, the grey relational analysis was used to analyze the dot reproduction attributes. Results showed that paper properties had a great influence on ink setting. Ink drop diffused and deformed less and dot gain was small when paper had smooth surface and tight texture. According to the correlation coefficient degree of paper properties which influence on the dot gain of inkjet printing, the sequence was whiteness, roughness, surface wettability and gloss. Whiteness and roughness could significantly influence dot gain, followed by surface wettability, and gloss with minimal impact. Experiments indicated that the grey relational analysis was a simple and effective tool to analyze the influence of paper properties on the dot reproduction of presswork.