We develop methods to predict printing machines components behavior in order to reduce cost, shorten production time, and to improve lifespan and print quality. These methods of optimization are based on finite element calculations using Abaqus program. Specifically, we model HP-Indigo's machine units, such as the printing blanket, an ink dispersion unit seal and a substrate coating unit. For each component we first characterize the materials by off-line measurements and propose appropriate material descriptions. Then the system is analyzed and dependence of its behavior on relevant parameters is found. This allows for optimization and proposing future configurations, where expensive and time consuming prototypes can be built and tested only for most preferable candidates. These methods are very interesting for a wide range of applications.