The water-based ink contains no volatile organic solvents and makes little environmental pollution, so it will be used widely as one promising environment-protecting ink. In order to promote the printability of water-based ink and make it to be one better promotion and application as the environmental protecting print materials. So this paper adopted dispersion method of high speed grinding to get the primary ink of water-based ink, studying on the influence of primary ink of water-base ink. The result indicated that, the performance of primary ink of water-based ink prepared by high speed grinding was good. The factors which influenced dispersion of primary ink included pigment/resin ratios, types of dispersant. The factor which influenced the surface tension of primary ink is substrate wetting agent. Different defoamers in the water-based ink had different results. The defoamer A8 had great efficiency of defoaming.