The performance of the printed devices generally depends on the drop landing accuracy. In a roll-to-roll ink-jet printing system, it is more difficult to control the drop landing accuracy because of the substrate distortion and web handling. Such distortion could arise from exposure to elevated temperatures, mechanical stresses from handling, changes in surface material compositions or moisture absorption. For the web handling, the important factors are the speed, tension and alignment. To study these printing issues, we have constructed a roll-to-roll ink-jet printing system whose web width is 30 cm. In this paper, the system is introduced and the results from experiments are shown and discussed.