To brew ink-jet printing (IJP) technology instead of traditional processes like spinning, screen printing, photolithography, and laser printing, used for semiconductor and display field, what is the obstacle before make mass production? The image compensation for printed thickness and resolution modulation control is the highest priority due to they dominate the device performance, especially for the roll-to-roll fabrication process. In this study, we tried to construct a novel algorithm to real-time calculate methodology to compensate the image distortion due to the thermal process and web delivery stress. Besides, this paper proposed a novel image trimming method based on the spreading factor between the liquid-solid interface and calculated image distortion, to real-time transfer the original image to a printing raster image data. In details, the trimming method included the procedure of pattern identification and locating, image separation, seamless image merge, image boundary compensation, image trimming on spreading factor, and image reconstruction, and the filtering method included the local characteristic of boundary inspection with defined correcting function and varied filtering pattern applied to inner field of boundary. To correct the landing position, this article designed new algorithm memory arbitration for the inconsistent between nozzle physical arrangement and printing data by rearranging the data format, to reduce the dispensing landing deviation.