There are many ways of using lasers to direct write or create an image of functional electronic material. However, one of the challenges of making electronic devices on flexible substrates is how to align one pattern with another pattern on a substrate which is dimensionally non uniform. We have developed a process that uses the initial pattern as an encoder for the subsequent pattern utilizing a unique algorithm called nDSE (nanometer Displacement Sensing and Estimation). We will show example of using this process in conjunction with laser delamination of thin metal from plastic substrate