In order to solve the difficulty in searching equipment manufacturing resources during outsourced processing of guide roller production operation for printing machine, this paper proposed an optimal selection method of cloud manufacturing resource for guide roller based on the combination algorithm of extensible clustering and fuzzy analytic hierarchy process (FAHP). First, the ontology model of cloud manufacturing demand (CMD) and cloud manufacturing resource (CMR) for guide roller are established based on the production process characteristics of the guide roller. Then, extension clustering algorithm was improved based on cloud manufacturing characteristics of guide rollers, and the improved extension clustering algorithm and FAHP were combined to achieve the selection of optimal guide roller production equipment CMR. Finally, the experimental analysis was conducted on the guide roller manufacturing data from Shaanxi Beiren Printing Machinery Co., Ltd. The results of the experiment demonstrate the feasibility and effectiveness of the proposed method. In summary, the above method can provide assistance for the intelligent and service-oriented transformation and upgrading of guide roller production and manufacturing.