Yongding River is one of the five major river systems in Beijing. It is located to the west of Beijing. It has influenced culture along its basin. The river supports both rural and urban areas. Furthermore, it influences economic development, water conservation, and the natural environment. However, during the past few decades, due to the combined effect of increasing population and economic activities, a series of changes have led to problems such as the reduction in water volume and the exposure of the riverbed. In this study, remote sensing images were used to derive land cover maps and compare spatiotemporal changes during the past 40 years. As a result, the following data were found: forest changed least; cropland area increased to a large extent; bareland area was reduced by a maximum of 63%; surface water area in the study area was lower from 1989 to 1999 because of the excessive use of water in human activities, but it increased by 92% from 2010 to 2018 as awareness about protecting the environment arose; there was a small increase in the built-up area, but this was more planned. These results reveal that water conservancy construction, agroforestry activities, and increasing urbanization have a great impact on the surrounding environment of the Yongding River (Beijing section). This study discusses in detail how the current situation can be attributed to of human activities, policies, economic development, and ecological conservation Furthermore, it suggests improvement by strengthening the governance of the riverbed and the riverside. These results and discussion can be a reference and provide decision support for the management of southwest Beijing or similar river basins in peri-urban areas.