Among various rapid prototyping methods, some are based on a conventional ink jet printing process. The three-dimensional (3D) printing process discussed uses powder material as a substrate and liquid binder as an ink. Three-dimensional prints are usually finished by an infiltrant agent prior to the final use. Epoxy resin, cyanoacrylate, and a polyurethane-based agent are regularly used. The impact of infiltrant type on the selected mechanical properties and surface appearance of 3D ink jet prints was the focus of the study. The type of infiltrant agent used greatly contributes to the discussed final properties of the prints. As a case study, the application of 3D printing in conventional printing technology was studied. The 3D prints can be used as a negative matrix for conventional photopolymer flexographic printing plate production. It is important that the applied infiltrant does not influence the 3D print dimensions, as well as provide the optimum combination of mechanical and surface properties.