We describe a novel real-time image processing and sensor fusion system for aerial vehicles in need of autonomous landing, guidance and obstacle avoidance. The Intelligent Synthetic Vision System (ISVS) described herein can process and display information merged from multiple image sources including a high resolution millimeter wave radar, a stored terrain with 3D airport database, FLIR, as well as visual reference images. The resulting solution provides safe all-time/all-visibility navigation in terrain-challenging areas and, in particular, real-time object detection during the final phases of landing in all weather conditions.