In the last 80 years, the role of spatial processing in the visual system has been analyzed and demonstrated from many studies and experiments. Starting from the first studies of Young, Helmholtz and Hering, color vision models have developed, and several biological and physiological research paper proved the importance of spatial processing in color vision. In this paper, we present some of the studies which have explored the role of spatial processing to study color vision deficiency. Main scope of this work is to increase the awareness of the scientific community on the importance to include spatial processing not only in color vision models, but also in developing color deficiency aids and tests.