In recent years, the rapid development of imaging systems and the growth of compute-intensive imaging algorithms have led to a strong demand for High Performance Computing (HPC) for efficient image processing. However, the two communities, imaging and HPC, have largely remained separate, with little synergy. This conference focuses on research topics that converge HPC and imaging research with an emphasis on advanced HPC facilities and techniques for imaging systems/algorithms and applications. In addition, the conference provides a unique platform that brings imaging and HPC people together and discusses emerging research topics and techniques that benefit both the HPC and imaging community. Papers are solicited on all aspects of research, development, and application of high-performance computing or efficient computing algorithms and systems for imaging applications.