Digital color cameras detect scenes through color filter array (CFA) of mosaic patterns. Among existing filter arrays in commercial CMOS image sensors (CIS), the CMY color filter set is one that is a more desirable choice for low-illuminating conditions. However, these color filters generally suffered from lower color fidelity than their counterpart RGB color filters. Nevertheless, the overall CIS performance were affected not only by the pigments used for color filters but also by the detailed structure designs and CFA arrangement of the pixel itself, we tends to explore the best combination for both the color filter materials and the pixel designs that will improve CIS performance for low light conditions that will have applications in astrophotography, low phototoxicity bioimaging, as well as general photography during dawn and dusk.