The Random spray Retinex (RSR) algorithm was developed by taking into consideration the mathematical description of Milano-Retinex. The RSR substituted random paths with random sprays. Mimicking some characteristics of the human visual system (HVS), this article proposes two variants of RSR adding a mechanism of region of interest (ROI). In the first proposed model, a cone distribution based on anatomical data is considered as ROI. In the second model, the visual resolution depending on the visual field based on the knowledge of visual information processing is considered as ROI. We have measured actual eye movements using an eye-tracking system. By using the eye-tracking data, we have simulated the HVS using test images. Results show an interesting qualitative computation of the appearance of the processed area around real gaze points.