Considerable work has been accomplished regarding the perceptibility of color differences for simple images. Less is known regarding color difference perceptibility when complex images are involved. In this research, psychophysical experimentation was conducted to determine if image content, in terms of memory color or image component size, is a significant factor in color difference perceptibility. A portrait, a nature scene, an image containing strictly man-made objects, and four mosaic images composed of different size patches were examined. The experimental results suggest that image component size affected the perceptibility of color differences while the presence of memory colors had no conclusive effect.