Individual differences in color matching functions are well known and have recently been well modeled and quantified. The phenomenon even carries a unique name, observer metamerism. However, to date, no research has explored the effects of observer metamerism (or other individual differences in physiological mechanisms) on chromatic adaptation and color appearance. This paper presents a computational study of the effects of observer metamerism on predicted corresponding colors, the result of chromatic adaptation. The ranges of predicted corresponding colors are computed, analyzed and explored. The differences in predicted chromatic adaptation (using a von Kries model) are very significant and could have practical importance. Additionally, a computation of the required precision in psychophysical experiments on chromatic adaptation indicates that the precision required to adequately model individual differences (well less than one CIELAB unit) is an order of magnitude better than that of previously published research on which models such as CIECAM02 are built.