This paper presents an experimental investigation of the application of multispectral imaging in dermatology. The focus areas of this work are as follows: a) the improving the color reproduction accuracy of skin lesions, b) exploring the spectral feature of skin disease using the multispectral color enhancement technique, and c) multispectral image analysis aiming at supporting quantitative diagnosis. The experiment focused on inflammatory and immunologic diseases; the color of skin lesions associated with these diseases is believed to be difficult to reproduce by conventional imaging devices. In view of this fact, we demonstrate the effectiveness of using spectral information for the color reproduction and quantitative analysis of skin disorders.