The current high-fidelity printing uses RGB images as original patterns, but the digital screening color matching program has adopted “CMYK+ spot color printing” method, which has a narrow color gamut and the phenomenon of metameric colors. Based on these problems, this study evaluated multispectral images as an image pattern for high-fidelity printing. However, multispectral images have too many color dimensions and information redundancy, which could not be used directly for printing. This study adopted the nonnegative principal component analysis method to reduce the dimensions of multispectral images to obtain the principal components of the colors, and the corresponding printing colors were selected. Finally, based on variable frequency amplitude modulation screening theory and its technical application rules, a new digital screening color matching program is proposed. Thus, more printing color inks could be used in high-fidelity printing output. Experimental results have shown that the new printing output method expanded the printing color gamut and reduced the degree of metamerism of the printed images. This novel idea and technical approach to achieve the high-fidelity printing has a significant theoretical and application value.