For mass production, multiple color halftoning screen printing (MCHSP) can be considered as the alternative textile printing technology when vivid color gradation is needed and cost for digital printing is concerned. Essentially, MCHSP utilizes the same equipment as traditional screen printing to print overlapped multiple color gradation under halftoning patterns by applying the dedicated treatments on color separation and calibration. In order to ensure the color quality, the equipment calibration and tone curve compensation are required to compensate the variables from equipment setup and heterogeneous fabrics. In this research, we provided the procedure of tone curve compensation to alleviate the discrepancy from heterogeneous fabrics. The experimental result based on 55 samples of 44 different fabrics shows the compensation effectiveness and reveal the distribution of average compensation percentage across fabrics.