Today, different models and instruments exist to study and model color vision and color vision deficiency. These systems are often modeled at spectral and retinal levels. In this study, we propose a novel approach to set up models and aids for color vision deficiencies, considering the role of spatial color processing in human visual system. In particular, we present the results of a perceptual test to identify the role of the spatial arrangement in color discrimination by Color Deficient Observers (CDOs) and Color Normal Observers (CNOs), using simultaneous contrast effect.