Although the current societal push for Science-Art collaboration is loud and omnipresent, its integration and practice is superficial. Science and Art disciplines offer a wealth of methodologies, processes, and outcomes relevant to understanding the fundamentals of the how and why of our behaviors, but they remain disconnected in part due to an overwhelming lack of understanding that their solid integration offers invaluable insight for major questions within the study of human cognition. In this paper I argue for a shift in perspective for empirical work in human cognition that genuinely combines and transforms elements from Science and Art to create (a) a new, hybrid discipline as well as (b) sets of new data from which to extract meaningful patterns. I specifically focus on applying integrative Science-Art investigation towards such questions as the relationship between music and language, emotion expression, and spontaneous, real-time adaptability in live, artistic contexts. I discuss a novel project within theatre with live musical improvisation to dissect the characteristics of a coherent, dramatic conversation.