A Low-power and low-noise digital pixel sensor (DPS) is presented in this paper. To design and analyze the random noise (RN) of the developed DPS, especially, we utilize a novel simulationmethod called transient-based AC noise simulation (TBAS) which can effectively help to estimate the noise components of the lowpowered single-slope (SS) analog-to-digital converter (ADC). Based on this noise analysis, the high performance DPS has been successfully designed and demonstrated.