Since it is essential for Computer Vision systems to reliably perform in safety-critical applications such as autonomous vehicles, there is a need to evaluate their robustness to naturally occurring image perturbations. More specifically, the performance of Computer Vision systems needs to be linked to the image quality, which hasn’t received much research attention so far. In fact, aberrations of a camera system are always spatially variable over the Field of View, which may influence the performance of Computer Vision systems dependent on the degree of local aberrations. Therefore, the goal is to evaluate the performance of Computer Vision systems under effects of defocus by taking into account the spatial domain. Large-scale Autonomous Driving datasets are degraded by a parameterized optical model to simulate driving scenes under physically realistic effects of defocus. Using standard evaluation metrics, the Spatial Recall Index (SRI) and the new Spatial Precision Index (SPI), the performance of Computer Vision systems on these degraded datasets are compared with the optical performance of the applied optical model. A correlation could be observed between the spatially varying optical performance and the spatial performance of Instance Segmentation systems.