Fundamentally, preservation is about ensuring the ongoing usability of valued content. The media which convey this content to a reader–paper, microform, CD-ROM, or online product–continue to change over time. But regardless of media variation, the fundamental goal of preservation does not change; the goal remains ensuring the longevity of the content. The challenge is to ensure that there are sufficient provisions and support for the successful transition of the content from one medium to another in a way that is compatible with the goal of long-term preservation.The likelihood of meeting this challenge is increased through a multi-faceted approach implemented within an organizational framework designed to provide the necessary support for the work of preservation. JSTOR, a not-for-profit organization with a mission focused on the long-term preservation of and access to scholarly resources, provides an opportunity to examine how content preservation and media transitions can be conducted within an organizational framework designed to robustly support this work. Drawing upon her experience as the former director of JSTOR's production unit and the leader of its Electronic-Archiving Initiative, the author suggests several elements useful for preserving journal literature in various media and highlights how these elements may be combined with key organizational components in order to meet the challenges of long-term content preservation. The preservation components discussed include stewardship of print originals, migration of print content to digital media, and preservation of electronic publications. These components by themselves, however, are insufficient to ensure the preservation of content; they will lead to preservation only when developed within an organizational context which includes an institutional commitment to the preservation goal; a business model which can ensure the sustainability of the archival operation; a technical infrastructure able to meet the demands of the content; and appropriate relationships with libraries and content owners and producers.