This research explores the effect of various eyewear lenses, designed with varied transmittance properties, on human visual perception. These lenses are developed to enhance contrast for spatial-chromatic patterns like cyan-red (CR) and magenta-green (MG) compared to lenses with more uniform transmittance. The study evaluates participants’ accuracy and response times in identifying contrast patterns, aiming to understand how different eyewear configurations affect these visual metrics. Two experiments were conducted: the first adjusted spatial frequencies to determine visibility thresholds with different eyewear, while the second utilized a 4-alternative forced-choice (4-AFC) method to measure participants’ ability to identify contrast patterns. Results indicate that eyewear with varied transmittance enhances contrast sensitivity for these chromatic pairs more effectively than uniform transmittance lenses, offering valuable insights into optimizing color-enhancing eyewear for improving certain aspects of visual performance and providing broader applications in enhancing human visual perception across various visual tasks.