Spot color is widely used in commercial, product or packaging printing to obtain a colorful appearance. With the combination of the right software, inks and media, an inkjet printer can be treated as a digital proofer for spot color printing, providing significant time and cost savings compared to conventional procedures for jobs approval. An Epson Stylus Pro 4000 digital printer combined with two commercially available RIPs were tested and compared. ICC profiles were generated for the Epson Stylus Pro 4000 printer, using the actual production printing substrate and manufacturer recommended proofing paper. Color gamuts of different output combinations were compared and the quality of spot color reproduction was evaluated in terms of the ΔE in L*a*b* color space for selected spot colors.