In the past few decades, there has been intensive research concerning the Unmixing of hyperspectral images. Some methods such as NMF, VCA, and N-FINDR have become standards since they show robustness in dealing with the unmixing of hyperspectral images. However, the research concerning the unmixing of multispectral images is relatively scarce. Thus, we extend some unmixing methods to the multispectral images. In this paper, we have created two simulated multispectral datasets from two hyperspectral datasets whose ground truths are given. Then we apply the unmixing methods (VCA, NMF, N-FINDR) to these two datasets. By comparing and analyzing the results, we have been able to demonstrate some interesting result for the utilization of VCA, NMF, and N-FINDR with multispectral datasets. Besides, this also demonstrates the possibilities in extending these unmixing methods to the field of multispectral imaging.